So, dairy is a bad choice when it comes to autophagy. Heavy cream or something similar has a much higher anabolic response than butter or coconut oil because it also has a bit of protein and sugar. It’s true that fat doesn’t spike insulin the same way carbs or protein do but it will still elevate mTOR and put you into a fed state. That can be replicated on a ketogenic diet and adding a little bit of ketone boosting fats to your coffee like MCT oil. Ketone bodies do stimulate chaperone-mediated autophagy and macroautophagy in the brain but ancestrally that happened primarily during starvation. What about adding some fats like butter, heavy cream or coconut oil? Read about Bulletproof Coffee and Fasting. You definitely want to avoid sugar, honey, or milk because they raise insulin and mTOR. The autophagic benefits of coffee probably apply to black coffee without many additives. And ’yes’, you can drink coffee in a fasted state without fearing that it’llīreak the fast or interfere with autophagy. So, the answer is ’no’, coffee doesn’t stop autophagy but actually boosts I don’t think adding salt or some minerals to your water breaks a fast and I don’t think coffee does so either. Drinking salted water could do those same things in your digestive tract but it has even fewer calories than coffee. If coffee were to break a fast because of increasing gut motility or liver enzyme activity, then the same would apply to regular water. However, I wouldn’t consider that as going into a fed state because all the anabolic hormones and energy substrates will remain suppressed. It would certainly affect your digestive organs and even raises metabolic rate. Some people may say that because you’re still digesting the calories and it stimulates your liver enzymes or gut bacteria that it’s still going to shift you into a fed state. Not enough to break a fast or shift you into a fed state. Does Coffee Break a FastĪ single cup of coffee has about 200 mg-s of caffeine and 4-5 calories. Not eating calories and fasting is an effective way to activate autophagyīut there are others like exercise, saunas, and even coffee.
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